KMID : 1134120190220020285
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Journal of Breast Cancer 2019 Volume.22 No. 2 p.285 ~ p.296
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The Benefit of Post-Mastectomy Radiotherapy in ypN0 Patients after Neoadjuvant Chemotherapy According to Molecular Subtypes
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Cho Won-Kyung
Park Won Choi Doo-Ho Kim Yong-Bae Kim Jin-Ho Kim Su-Ssan Kim Kyu-Bo Kim Jin-Hee Ahn Sung-Ja Lee Sun-Young Lee Jeong-Shim Kim Sang-Won Kwon Jeanny Ahn Ki-Jung
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Abstract
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Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype.
Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes.
Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes.
Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.
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KEYWORD
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Breast neoplasms, Mastectomy, Neoadjuvant treatment, Radiotherapy
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